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Dysbiosis of the Gut Microbiota and Kynurenine (Kyn) Pathway Activity as Potential Biomarkers in Patients with Major Depressive Disorder

Studies suggest that it may achieve this by downregulating pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-) and interleukin-6 (IL-6) while upregulating anti-inflammatory mediators like interleukin-10 (IL-10)

doi: 10.1080/02648725.1985.10647818 53 FakankunI.SpicerV.LevinD

In addition to iron-catalyzed free radical chain reactions, lipoxygenase (LOXs) can directly oxidize PUFAs and lipid-containing PUFAs in cell membranes, which are considered to have an essential role in ferroptosis [75, 80]